Dr Sarah Holdsworth-Carson
Dr Sarah Holdsworth-Carson is a well-recognized fundamental research scientist in the endometriosis field. She has more than 10 years’ research experience at the Royal Women’s Hospital and is a Senior Research Fellow (Honorary) at the University of Melbourne in the Department of Obstetrics and Gynaecology. In 2021, Sarah was recruited as the Research Program Manager at the Julia Argyrou Endometriosis Centre at Epworth. Sarah’s research is driven by the concept that better outcomes for patients with endometriosis starts by improving our basic understanding of disease mechanisms through laboratory-based discovery research in partnership with clinical research. Using this ‘bench-to-bedside’ translational approach as part of a multidisciplinary team, Sarah hopes to improve endometriosis diagnosis strategies and develop better disease classification tools that account for patient phenotypes and experiences of disease.
Publications
2021
Colgrave, E.M., S. Bittinger, M. Healey, U.P. Dior, P.A.W. Rogers, J.R. Keast, J.E. Girling, and S.J. Holdsworth-Carson, Reply: The heterogeneity of endometriotic lesions could be explained by their progesterone resistance. Hum Reprod, 2021.
2021
Holdsworth-Carson, S.J., M. Churchill, J.F. Donoghue, S. Mortlock, J.N. Fung, C. Sloggett, J. Chung, L. Cann, W.T. Teh, K.R. Campbell, R. Luwor, M. Healey, G. Montgomery, J.E. Girling, and P.A.W. Rogers, Elucidating the role of long intergenic non-coding RNA 339 in human endometrium and endometriosis. Mol Hum Reprod, 2021. 27(3).
2021
Marla, S., S. Mortlock, S. Houshdaran, J. Fung, B. McKinnon, S.J. Holdsworth-Carson, J.E. Girling, P.A.W. Rogers, L.C. Giudice, and G.W. Montgomery, Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium. Mol Hum Reprod, 2021. 27(1).
2020
Mortlock, S., R.I. Kendarsari, J.N. Fung, G. Gibson, F. Yang, R. Restuadi, J.E. Girling, S.J. Holdsworth-Carson, W.T. Teh, S.W. Lukowski, M. Healey, T. Qi, P.A.W. Rogers, J. Yang, B. McKinnon, and G.W. Montgomery, Tissue specific regulation of transcription in endometrium and association with disease. Hum Reprod, 2020. 35(2): p. 377-393.
2020
Colgrave, E.M., S. Bittinger, M. Healey, U.P. Dior, P.A.W. Rogers, J.R. Keast, J.E. Girling, and S.J. Holdsworth-Carson, Superficial peritoneal endometriotic lesions are histologically diverse and rarely demonstrate menstrual cycle synchronicity with matched eutopic endometrium. Hum Reprod, 2020. 35(12): p. 2701-2714.
2020
Holdsworth-Carson, S.J., J. Chung, C. Sloggett, S. Mortlock, J.N. Fung, G.W. Montgomery, U.P. Dior, M. Healey, P.A. Rogers, and J.E. Girling, Obesity does not alter endometrial gene expression in women with endometriosis. Reprod Biomed Online, 2020. 41(1): p. 113-118.
2019
Dior, U.P., D. Nisbet, J.N. Fung, G. Foster, M. Healey, G.W. Montgomery, P.A.W. Rogers, S.J. Holdsworth-Carson, and J.E. Girling, The Association of Sonographic Evidence of Adenomyosis with Severe Endometriosis and Gene Expression in Eutopic Endometrium. J Minim Invasive Gynecol, 2019. 26(5): p. 941-948.
2019
Mortlock, S., R. Restuadi, R. Levien, J.E. Girling, S.J. Holdsworth-Carson, M. Healey, Z. Zhu, T. Qi, Y. Wu, S.W. Lukowski, P.A.W. Rogers, J. Yang, A.F. McRae, J.N. Fung, and G.W. Montgomery, Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases. Clin Epigenetics, 2019. 11(1): p. 49.
2019
Holdsworth-Carson, S.J., E.M. Colgrave, J.F. Donoghue, J.N. Fung, M.L. Churchill, S. Mortlock, P. Paiva, M. Healey, G.W. Montgomery, J.E. Girling, and P.A.W. Rogers, Generation of immortalized human endometrial stromal cell lines with different endometriosis risk genotypes. Mol Hum Reprod, 2019. 25(4): p. 194-205.
2018
Fung, J.N., S. Mortlock, J.E. Girling, S.J. Holdsworth-Carson, W.T. Teh, Z. Zhu, S.W. Lukowski, B.D. McKinnon, A. McRae, J. Yang, M. Healey, J.E. Powell, P.A.W. Rogers, and G.W. Montgomery, Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome. Sci Rep, 2018. 8(1): p. 11424.
2017
Fung, J.N., J.E. Girling, S.W. Lukowski, Y. Sapkota, L. Wallace, S.J. Holdsworth-Carson, A.K. Henders, M. Healey, P.A.W. Rogers, J.E. Powell, and G.W. Montgomery, The genetic regulation of transcription in human endometrial tissue. Hum Reprod, 2017. 32(4): p. 893-904.
2016
Powell, J.E., J.N. Fung, K. Shakhbazov, Y. Sapkota, N. Cloonan, G. Hemani, K.M. Hillman, S. Kaufmann, H.T. Luong, L. Bowdler, J.N. Painter, S.J. Holdsworth-Carson, P.M. Visscher, M.E. Dinger, M. Healey, D.R. Nyholt, J.D. French, S.L. Edwards, P.A. Rogers, and G.W. Montgomery, Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339. Hum Mol Genet, 2016. 25(22): p. 5046-5058.
2016
Holdsworth-Carson, S.J., J.N. Fung, H.T. Luong, Y. Sapkota, L.M. Bowdler, L. Wallace, W.T. Teh, J.E. Powell, J.E. Girling, M. Healey, G.W. Montgomery, and P.A. Rogers, Endometrial vezatin and its association with endometriosis risk. Hum Reprod, 2016. 31(5): p. 999-1013.
2015
Fung, J.N., S.J. Holdsworth-Carson, Y. Sapkota, Z.Z. Zhao, L. Jones, J.E. Girling, P. Paiva, M. Healey, D.R. Nyholt, P.A. Rogers, and G.W. Montgomery, Functional evaluation of genetic variants associated with endometriosis near GREB1. Hum Reprod, 2015. 30(5): p. 1263-75.
